insurmountable - significado y definición. Qué es insurmountable
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Qué (quién) es insurmountable - definición

CLASS OF PHARMACOLOGICAL AGENTS, WHICH REDUCES OR DIMINISHES THE EFFECT OF AN AGONIST ON A RECEPTOR
Competitive antagonist; Neutral antagonist; Receptor antagonists; Receptor Antagonist; Receptor Antagonists; Antagonist (pharmacology); Receptor antagonism; Antagonist (medical); Antagonist drug; Antagonist (drug); Silent antagonist; Uncompetitive antagonist; Noncompetitive antagonist; Reversible competitive antagonist; Irreversible competitive antagonist; Non-competitive antagonist; Reversible antagonist; Insurmountable antagonist; Full antagonist; Silent antagonism; Noncompetitive antagonism; Non-competitive antagonism; Blocking agent; Functional inhibition; Functional antagonism
  • receptor]] molecule, inhibiting the signal produced by a receptor–agonist coupling.
  • Chart demonstrating the difference between agonists, silent antagonists, and inverse agonists.<ref name="Rang2020" />
  • Agonists get its maximum effect reduced when in the presence of an Irreversible Competitive Antagonist or a Reversible Non-Competitive Antagonist.<ref name="Rang2020" />
  • oclc=1081403059}}</ref>

Insurmountable      
·adj Incapable of being passed over, surmounted, or overcome; insuperable; as, insurmountable difficulty or obstacle.
insurmountable      
a.
insurmountable      
[??ns?'ma?nt?b(?)l]
¦ adjective too great to be overcome.
Derivatives
insurmountably adverb

Wikipedia

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins. They are sometimes called blockers; examples include alpha blockers, beta blockers, and calcium channel blockers. In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. Antagonists mediate their effects by binding to the active site or to the allosteric site on a receptor, or they may interact at unique binding sites not normally involved in the biological regulation of the receptor's activity. Antagonist activity may be reversible or irreversible depending on the longevity of the antagonist–receptor complex, which, in turn, depends on the nature of antagonist–receptor binding. The majority of drug antagonists achieve their potency by competing with endogenous ligands or substrates at structurally defined binding sites on receptors.

Ejemplos de uso de insurmountable
1. June, however, found the language barrier insurmountable.
2. The government‘s majority is no longer insurmountable.
3. "However, such spread is not insurmountable," Dr.
4. Indeed, the challenges seemed close to insurmountable.
5. Jones faces employment prospects that he calls insurmountable.